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Objective To study repairing effect of Lugua polypeptide on patients with spinal cord injury and the related mechanism. Methods From August 2012 to August 2013,79 cases patients with thoracolumbar spinal cord injury as the research objects,and they were divided into two groups randomly.The control group (n=38)received conventional treatment,and the observation group (n=41)received intravenous drip of Lugua polypeptide on the basis of conventional treatment.The course is three months.The American spinal injury association(ASIA)sensory score,ASIA motor score and Bathel index (BI )were recorded in two groups before and after treatment.Analyse the repairing effect on patients with spinal cord injury. Results ASIA sensory score,ASIA motor score and Bathel index in two groups after treatment improved ,and the observation group improved significantly compared with control group(P<0.05).Conclusion Lugua polypeptide can improve sensory and motor function with spinal cord injury ,it has clinical value.
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Objective To study the clinical therapeutic effect of arthroscopic debridement cooperated with injecting chuanxiongqin in treating knee osteoarthritis. Methods Sixty cases of knee osteoarthritis were randomly divided into 2 groups: treating group and control group, 30 cases in each group. The treating group were treated by arthroscopic debridement cooperated with injecting chuanxiongqin;the control group were given hyaluronate-Na after received arthroscopic debridement. The operation evaluation criteria of JOA was taken to value the therapeutic effect at 1 week, 3 months, 6 months and 12 months postoperation. At the same time, nitric oxide (NO) content in joint fluid were measured at preoperation, 1 week, 4 weeks, 3 months postoperation. Results At 1 week postoperation, there were no statistically significant differenced > 0.05) between the two groups,at 3, 6 and 12 months postoperation, the therapeutic effect of the treating group were much better than those of the control group (P < 0.01);NO content in joint fluid of preoperative treatment group [(90.32 ± 22.24) μmol/L]and control group [(90.31 ±22.20) μ mol/L]was similar, there was no significant difference (P >0.05). At 3 months postoperation, NO content in joint fluid of the treating group [(85.63 ± 30.63) μ mol/L]decreased significantly compared with preoperative (P < 0.05 ) , and the content was much lower than that of the control group [(89.66 ± 20.63 ) μ mol/L], there was significant difference between the two groups (P < 0.05). Although NO content in joint fluid of the control group was decreased, but the difference was not statistically significant (P >0.05). Conclusions Arthroscopic debridement with injecting chuanxiongqin in treating knee osteoarthritis can control inflammatory reaction of cartilage and synovia]in effect, improve the therapeutic effect. Therefore, it should be avalid method in treating knee osteoarthritis.
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Objective To study the therapeutic effect of sodium aescinate for injection combined with percutaneous laser disc decompression (PLDD) in treating lumbar disc herniation (LDH). Methods Ninety-eight cases of LDH were divided into 2 groups by means of random number table: treating group and control group, 49 cases in each group. The treating group were given the treatment of sodium aescinate for injection after received PLDD,the control group were given mannitol for injection after received PLDD. The operation evaluation criteria of lumbago and backache of Chinese medical association spine group was taken to value the therapeutic effect at 7 days, 1 month, 3 months and 6 months postoperation. At the same time,C-reactive protein (CRP) content in serum were measured at preoperation and 1, 3, 7 days postoperation.Results At 7 days postoperation, the excellent and good rate of the treating group was significantly higher than that of the control group[93.9%(46/49) vs. 55.1%(27/49),P ＜ 0.01], at 1, 3 and 6 months postoperation,the excellent and good rate had no statistically significant between the two groups (P ＞0.05). At 3 days postoperation, the serum CRP content in the treating group [(13.0 ± 2.2) mg/L] was lower than that of the control group [(31.0 ± 5.3) mg/L], there were significant differences between the two groups (P ＜ 0.01).Conclusions Sodium aescinate for injection combined with PLDD can control postoperative inflammation reaction effectively, improve the therapeutic effect. Therefore it should be a valid method in treating LDH.